Article

Human V-ATPase a-subunit isoforms bind specifically to distinct phosphoinositide phospholipids

2023-04-24

Abstract excerpt

<h4>ABSTRACT</h4> V-ATPases are highly conserved multi-subunit enzymes that maintain the distinct pH of eukaryotic organelles. The integral membrane a-subunit is encoded by tissue and organelle specific isoforms, and its cytosolic N-terminal domain (aNT) modulates organelle specific regulation and targeting of V-ATPases. Organelle membranes have specific phosphatidylinositol phosphate (PIP) lipid enrichment linke...

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Literature Corpus work: 6a4b7d72-9095-5423-bfc5-01489a916364
DOI: 10.1101/2023.04.24.538068

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