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Article

N-linked glycosylation of a subunit isoforms is critical for vertebrate vacuolar H+ -ATPase (V-ATPase) biosynthesis.

Journal of cellular biochemistry - 1 Jan 2018

Esmail Sally, Kartner Norbert, Yao Yeqi, Kim Joo Wan, Reithmeier Reinhart A F, Manolson Morris F

Abstract excerpt

The a subunit of the V0 membrane-integrated sector of human V-ATPase has four isoforms, a1-a4, with diverse and crucial functions in health and disease. They are encoded by four conserved paralogous genes, and their vertebrate orthologs have positionally conserved N-glycosylation sequons within the second extracellular loop, EL2, of the a subunit membrane domain. Previously, we have shown directly that the...

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Source

Identifiers

PMID: 28661051
DOI: 10.1002/jcb.26250

Genes

VMA21

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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