Article
Big1 is a newly identified autophagy regulator that is critical for a fully functional V-ATPase.
Molecular biology of the cell - 1 Nov 2024
Lei Yuchen, Yang Ying, Zhang Zhihai, Zhang Ruoxi, Song Xinxin, Malek Sami N, Tang Daolin, Klionsky Daniel J
Abstract excerpt
The vacuolar-type H+-translocating ATPase (V-ATPase) is the major proton pump for intraorganellar acidification. Therefore, the integrity of the V-ATPase is closely associated with cellular homeostasis, and mutations in genes encoding V-ATPase components and assembly factors have been reported in certain types of diseases. For instance, the recurrent mutations of ATP6AP1, a gene encoding a V-ATPase accessory...
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