Article

Skeletal muscle regeneration is altered in the R6/2 mouse model of Huntington’s disease

2022-01-12

Abstract excerpt

Huntington’s disease (HD) is caused by CAG repeat expansion in the huntingtin ( HTT ) gene. Skeletal muscle wasting alongside central pathology is a well-recognized phenomenon seen in patients with HD and HD mouse models. HD muscle atrophy progresses with disease and affects prognosis and quality of life. Satellite cells, progenitors of mature skeletal muscle fibers, are essential for proliferation, differentiati...

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Literature Corpus work: 6a439805-2bb8-556c-a57c-c4983d3fa8c5
DOI: 10.1101/2022.01.11.475914

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