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Rational design of a multi epitope vaccine against Salmonella typhi via subtractive proteomics, reverse vaccinology and molecular modeling

1 Sept 2025

Abstract excerpt

Salmonella enterica subsp. enterica serotype Typhi (Salmonella typhi) is the cause of typhoid fever, a severe public health issue in impoverished countries with inadequate sanitation. Despite the availability of therapies, infection rates remain high, underscoring the critical need for an effective and long-lasting vaccine. In this study, we used an integrated in silico strategy to develop a multi-epitope vaccine...

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PMID: 40890251
DOI: 10.1038/s41598-025-15254-8

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