Article

KLF2 is a therapeutic target for COVID-19 induced endothelial dysfunction

2021-02-20

Abstract excerpt

Coronavirus disease 2019 (COVID-19) is regarded as an endothelial disease (endothelialitis) with its mechanism being incompletely understood. Emerging evidence has demonstrated that the endothelium represents the Achilles' heel in COVID-19 patients and that endothelial dysfunction precipitates COVID-19 and accompanying multi-organ injuries. Thus, pharmacotherapies targeting endothelial dysfunction have potential t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69edc37f-dcad-5449-bd0c-9163c6a6b3d9
DOI: 10.1101/2021.02.20.432085

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

KLF2 is a therapeutic target for COVID-19 induced endothelial dysfunctionDOI 10.1101/2021.02.20.432085Read

Endothelial Cell Contributions to COVID-19Semantic proximity Read

Endothelium Infection and Dysregulation by SARS-CoV-2: Evidence and Caveats in COVID-19Semantic proximity Read

Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approachesSemantic proximity Read

Vascular underpinning of COVID-19Semantic proximity Read

SARS-CoV-2 induced vascular endothelial dysfunction: direct or indirect effects?Semantic proximity Read

Cardiovascular Signatures of COVID-19 Predict Mortality and Identify Barrier Stabilizing TherapiesSemantic proximity Read

IL-1β and TNF drive endothelial dysfunction and coagulopathy in acute COVID-19Semantic proximity Read

Comparative analysis of immune-associated genes in COVID-19, cardiomyopathy and venous thromboembolismSemantic proximity Read

Endothelial dysfunction in COVID-19: Insights from bronchoalveolar lavage and molecular markersSemantic proximity Read

Vascular Inflammatory Diseases and Endothelial Phenotypes.Semantic proximity Read

SARS-CoV-2 uses major endothelial integrin αvβ3 to cause vascular dysregulation in-vitro during COVID-19.Semantic proximity Read

miR-98 Regulates TMPRSS2 Expression in Human Endothelial Cells: Key Implications for COVID-19Semantic proximity Read