Article

Pirfenidone affects human cardiac fibroblast proliferation and cell cycle activity in 2D cultures and engineered connective tissues

2022-08-24

Abstract excerpt

<h4>Purpose: </h4> The anti-fibrotic drug pirfenidone (PFD) is currently in clinical testing for the treatment of heart failure with preserved ejection fraction, however, its effects on human cardiac cells have not been fully investigated. Therefore, we aimed to characterize the impact of PFD on human cardiac fibroblasts (CF) in 2D culture as well as in 3D engineered connective tissues (ECT). Methods We analyzed...

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Literature Corpus work: 69b4cd03-2e72-57c3-93ec-68ae77571286
DOI: 10.21203/rs.3.rs-1968389/v1

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