Article
Using different geometries to modulate the cardiac fibroblast phenotype and the biomechanical properties of engineered connective tissues.
Biomaterials advances - 1 Aug 2022
Santos Gabriela L, DeGrave Alisa N, Rehman Abdul, Al Disi Sara, Xhaxho Kristin, Schröder Helen, Bao Guobin, Meyer Tim, Tiburcy Malte, Dworatzek Elke, Zimmermann Wolfram-Hubertus, Lutz Susanne
Abstract excerpt
Tissue engineering with human cardiac fibroblasts (CF) allows identifying novel mechanisms and anti-fibrotic drugs in the context of cardiac fibrosis. However, substantial knowledge on the influences of the used materials and tissue geometries on tissue properties and cell phenotypes is necessary to be able to choose an appropriate model for a specific research question. As there is a clear lack of information on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.