Article

Plasma Glial Fibrillary Acidic Protein and Neurofilament Light are Elevated in Bipolar Disorder: Evidence for Neuroprogression and Astrocytic Activation

2024-07-31

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Importance</h4> Recent methodological developments allow us to measure small amounts of brain-specific proteins in the blood, including neurofilament light chain (NfL), a marker of axonal pathology, and glial fibrillary acidic protein (GFAP), a marker of astrocytic activation. Given the evidence of potential astroglial pathology and neuronal dysfunction in bipolar disorder, these markers may...

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Literature Corpus work: 69a80a98-56bd-5688-b28d-2475140a9f44
DOI: 10.1101/2024.07.30.24311203

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