Article

Calling small variants with universality and Bayesian-frequentist hybridism

2020-08-24

Abstract excerpt

The accuracy of variant calling is crucially important in clinical settings, as the misdiagnosis of a genetic disease such as cancer can compromise patient survival. Although many variant callers were developed, variant-calling accuracy is still insufficient for clinical applications. Here we describe UVC, a method for calling small variants of germline or somatic origin. By combining contrary assumptions with sub...

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Identifiers and source

Literature Corpus work: 697a9c43-0625-5072-a9ec-2ee432a5e29e
DOI: 10.1101/2020.08.23.263749

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