Article

Differential yet integral contributions of Nrf1 and Nrf2 in the human antioxidant cytoprotective response against <i>tert</i> -butylhydroquinone as a pro-oxidative stressor

2021-06-05

Abstract excerpt

In the past 25 years, Nrf2 had been preferentially parsed as a master hub of regulating antioxidant, detoxification and cytoprotective genes, albeit as a matter of fact that Nrf1, rather than Nrf2, is indispensable for cell homeostasis and organ integrity during normal growth and development. Here, distinct genotypic cell lines ( Nrf1α −/− , Nrf2 −/−ΔTA and caNrf2 ΔN ) are employed to determine differential y...

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Literature Corpus work: 6933c881-809e-5b28-8f29-0d94a0899f9f
DOI: 10.1101/2021.06.05.447190

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