Article

mTORC1 Suppression by Trp53 Mutation Drives Resistance to Immune Checkpoint Blockade

2025-12-17

Abstract excerpt

<title>Abstract</title> <p> p53 is a critical tumor suppressor gene that inhibits cancer development by regulating cell cycle arrest, apoptosis, DNA repair, and metabolism. However, recent studies examining <italic>TP53</italic> mutations in cancer immunotherapy have yielded inconsistent results, likely due to differences in tumor mutational burden (TMB) and the context-dependent roles of specific p53 mutants....

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Literature Corpus work: 691e8aed-1223-5600-a1ba-08825ac71dde
DOI: 10.21203/rs.3.rs-8214123/v1

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