Article

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

2019-10-02

Abstract excerpt

<h4>Aims</h4> Common chromosome 9p21 SNPs increase coronary heart disease (CHD) risk, independent of “traditional lipid risk factors”. However, lipids comprise large numbers of structurally-related molecules not measured in traditional risk measurements, and many have inflammatory bioactivities. Here we applied lipidomic and genomic approaches to three model systems, to characterize lipid metabolic changes in com...

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Literature Corpus work: 6844c28f-172e-53c9-9e77-8e441845571f
DOI: 10.1101/789768

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