Article

Echinocandin heteroresistance causes prophylaxis failure and facilitates breakthrough<i>Candida parapsilosis</i>infection

2022-05-29

Abstract excerpt

Breakthrough infections of patients on antimicrobial prophylaxis represent a significant and often unexplained cause of morbidity. Here, we reveal that in high-risk patients on micafungin prophylaxis heteroresistance – the presence of a phenotypically unstable, low frequency subpopulation of resistant cells (∼1 in 10,000) – underlies breakthrough bloodstream infections by Candida parapsilosis misclassified as susc...

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Literature Corpus work: 3ec5134f-9aca-572a-aaac-2f88a6846f53
DOI: 10.1101/2022.05.29.22275734

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