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Article

Mechanisms of targeted therapy resistance take a de-TOR.

Cancer cell - 9 Sept 2013

Gentry Leanna R, Martin Timothy D, Der Channing J

Abstract excerpt

The effectiveness of cancer therapeutics targeting signal transduction pathways is comprised of a diversity of mechanisms that drive de novo or acquired resistance. Two recent studies identify mTOR activation as a point of convergence of mechanisms that cause resistance to inhibitors of the Raf-MEK-ERK and PI3K signaling.

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Source

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Identifiers

PMID: 24029226
DOI: 10.1016/j.ccr.2013.08.021
PMCID: PMC3810955

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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