Article

7q11.23 Syndromes Reveal BAZ1B as a Master Regulator of the Modern Human Face and Validate the Self-Domestication Hypothesis

2019-03-06

Abstract excerpt

Symmetrical 7q11.23 dosage alterations cause craniofacial and cognitive/behavioral phenotypes that provide a privileged entry point into the evolution of the modern human face and (pro-) sociality. We undertook a functional dissection of chromatin remodeler BAZ1B in neural crest stem cells (NCSCs) from a uniquely informative cohort of typical and atypical patients harboring 7q11.23 Copy Number Variants (CNVs). Our...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 68141aee-4a4d-518f-b385-14374f9986b1
DOI: 10.1101/570036

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

7q11.23 Syndromes Reveal BAZ1B as a Master Regulator of the Modern Human Face and Validate the Self-Domestication HypothesisDOI 10.1101/570036Read

Genes Affecting Vocal and Facial Anatomy Went Through Extensive Regulatory Divergence in Modern HumansSemantic proximity Read

Gene expression patterns of the developing human face at single cell resolution reveal cell type contributions to normal facial variation and disease riskSemantic proximity Read

The craniofacial shape of modern humans embodies genomic signatures of evolution, diversity, and clinical conditionsSemantic proximity Read

Modern human changes in regulatory regions implicated in cortical developmentSemantic proximity Read

Cell Cycle Arrest of a ‘Zippering’ Epithelial Cell Cluster Shapes the Face and is Disrupted in Craniofacial DisordersSemantic proximity Read

Behavioural analysis of loss of function zebrafish supports baz1b as master regulator of domesticationSemantic proximity Read

Shared heritability of face and brain shape distinct from cognitive traitsSemantic proximity Read

Insights into the genetic architecture of the human face.Semantic proximity Read

Differential DNA methylation of vocal and facial anatomy genes in modern humans.Semantic proximity Read

Joint Multi-Ancestry and Admixed GWAS Reveals the Complex Genetics behind Human Cranial Vault ShapeSemantic proximity Read

Craniofacial developmental biology in the single-cell eraSemantic proximity Read

Novel genetic loci affecting facial shape variation in humans.Semantic proximity Read