Article

Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

2024-07-26

Abstract excerpt

<h4> ABSTRACT </h4> Repairing programmed DNA double-strand breaks (DSBs) is crucial in the lifecycle of Paramecium tetraurelia , especially during its sexual reproduction phase when its somatic highly polyploid macronucleus is lost. The formation of a new macronucleus involves Programmed Genome Rearrangements, introducing DNA DSBs at approximately 45,000 loci. P. tetraurelia employs a Non-Homologous End Joinin...

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Literature Corpus work: 6802a74f-4553-59c7-b49e-b7490668bad2
DOI: 10.1101/2024.07.26.605286

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