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SARS-CoV-2-mediated dysregulation of metabolism and autophagy uncovers host-targeting antivirals

21 Jun 2021

Abstract excerpt

Abstract Viruses manipulate cellular metabolism and macromolecule recycling processes like autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune responses as observed in severe and long COVID-19 patients. Here we show that SARS-CoV-2 modulates cellular metabolism and reduces autophagy. Accordingly, compound-driven induction of autophagy limits SARS-CoV-2 propagation. In detail,...

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PMID: 34155207
DOI: 10.1038/s41467-021-24007-w

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