Article

Avoidance of pyroptosis accounts for the relatively high metastatic potential observed in early hybrid EMT states

2025-01-27

Abstract excerpt

<h4>Summary</h4> EMT converts epithelial (E) phenotypes to invasive mesenchymal (M) states. However, analyses of circulating tumor cells (CTCs) indicated that biphenotypic (E+M) CTCs better correlate with metastasis. Similarly, investigations of murine tumors undergoing EMT concluded that early E+M states posses the highest metastatic potential. To explore this, we selected in animals with breast cancer CTCs havi...

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Literature Corpus work: 678718c8-9e5b-5415-a316-84a578169015
DOI: 10.1101/2025.01.26.634904

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