Article

Reversing Mitochondrial Dysfunction in Optineurin E50K Glaucoma: A Metabolic Approach to Neuroprotection

2026-02-19

Abstract excerpt

<title>Abstract</title> <p>Mutations in optineurin (OPTN) are linked to neurodegenerative diseases such as normal tension glaucoma (NTG) and amyotrophic lateral sclerosis. The E50K-OPTN mutation is the most common genetic cause of NTG, where it disrupts mitophagy and leads to the accumulation of dysfunctional mitochondria. To understand how cellular metabolism is altered in these persistent mitochondria, and whet...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6752be58-7a05-5227-89ea-6c765024631e
DOI: 10.21203/rs.3.rs-8380062/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Reversing Mitochondrial Dysfunction in Optineurin E50K Glaucoma: A Metabolic Approach to NeuroprotectionDOI 10.21203/rs.3.rs-8380062/v1Read

Mitophagy: An Emerging Target in Ocular PathologySemantic proximity Read

Disruption of mitochondrial homeostasis and permeability transition pore opening in OPA1 iPSC-derived retinal ganglion cellsSemantic proximity Read

Mitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationSemantic proximity Read

Glaucoma-associated Optineurin mutations increase transmitophagy in a vertebrate optic nerveSemantic proximity Read

Protein misfolding and mitochondrial dysfunction in glaucomaSemantic proximity Read

Optineurin Increases Cell Survival and Translocates to the Nucleus in a Rab8-dependent Manner upon an Apoptotic StimulusSemantic proximity Read

Glaucoma-associated Optineurin mutations increase transcellular degradation of mitochondria in a vertebrate optic nerve.Semantic proximity Read

Genetic and pharmacological correction of impaired mitophagy in retinal ganglion cells rescues glaucomatous neurodegenerationSemantic proximity Read

The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a reviewSemantic proximity Read

Glaucoma-Associated Mutations in the Optineurin Gene Have Limited Impact on Parkin-Dependent MitophagySemantic proximity Read

Meclizine rescues cardiac function and mitochondrial ultrastructure by ATP- and glycolysis-independent mechanisms in a genetic model of mitochondrial energy dysfunctionSemantic proximity Read

Mitochondrial dysfunction in glaucoma: closing the loop.Semantic proximity Read