Article

The CD28-transmembrane domain mediates chimeric antigen receptor heterodimerization with CD28

2020-09-19

Abstract excerpt

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge (HD) and transmembrane (TMD) domains between the extracellular antigen-targeting and the intracellular signaling modalities of CARs has not been systemically studied. Here, a series of CD19-CARs differing only by their HD (CD8/CD28/IgG 4 ) and TMD (CD8/CD28) was generated. CARs con...

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Literature Corpus work: 6742bdd7-bee2-546e-8fc0-9d07a6401d7c
DOI: 10.1101/2020.09.18.296913

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