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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28

23 Mar 2021

Abstract excerpt

Anti-CD19 chimeric antigen receptor (CD19-CAR)-engineered T cells are approved therapeutics for malignancies. The impact of the hinge domain (HD) and the transmembrane domain (TMD) between the extracellular antigen-targeting CARs and the intracellular signaling modalities of CARs has not been systemically studied. In this study, a series of 19-CARs differing only by their HD (CD8, CD28, or IgG 4 ) and TMD (CD8 or...

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PMID: 33833759
DOI: 10.3389/fimmu.2021.639818

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