Article
The p53 knowledgebase: an integrated information resource for p53 research.
Oncogene - 8 Mar 2007
Lim Y P, Lim T T, Chan Y L, Song A C M, Yeo B H, Vojtesek B, Coomber D, Rajagopal G, Lane D
Abstract excerpt
The p53 tumor suppressor protein plays a central role in maintaining genomic integrity by occupying a nodal point in the DNA damage control pathway. Here it integrates a wide variety of signals, responding in one of several ways, that is, cell cycle arrest, senescence or programmed cell death (apoptosis). Mutations in the tumor suppressor gene tp53, which affects the key transcriptional regulatory processes in...
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