Article

SARS-CoV-2 specific memory B-cells from individuals with diverse disease severities recognize SARS-CoV-2 variants of concern

2021-06-03

Abstract excerpt

In this investigation we examined the magnitude, breadth, and durability of SARS-CoV-2 specific antibodies in two distinct B-cell compartments: long-lived plasma cell-derived antibodies in the plasma, and peripheral memory B-cells along with their associated antibody profiles elicited after in vitro stimulation. We found that magnitude varied amongst individuals, but was the highest in hospitalized subjects. Vari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66e308dc-4775-5cf8-ae83-2f6c9a367478
DOI: 10.1101/2021.05.28.21258025

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SARS-CoV-2 specific memory B-cells from individuals with diverse disease severities recognize SARS-CoV-2 variants of concernDOI 10.1101/2021.05.28.21258025Read

No substantial pre-existing B cell immunity against SARS-CoV-2 in healthy adultsSemantic proximity Read

Maturation and persistence of the anti-SARS-CoV-2 memory B cell responseSemantic proximity Read

Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seqSemantic proximity Read

S protein-reactive IgG and memory B cell production after human SARS-CoV-2 infection includes broad reactivity to the S2 subunitSemantic proximity Read

Persistence of Functional Memory B Cells Recognizing SARS-CoV-2 Variants Despite Loss of Specific IgGSemantic proximity Read

A public antibody class recognizes a novel S2 epitope exposed on open conformations of SARS-CoV-2 spikeSemantic proximity Read

Rapid and lasting generation of B-cell memory to SARS-CoV-2 spike and nucleocapsid proteins in COVID-19 disease and convalescenceSemantic proximity Read

Maturation and persistence of the anti-SARS-CoV-2 memory B cell responseSemantic proximity Read

Asymptomatic or Symptomatic SARS-CoV-2 Infection Plus Vaccination Confers Increased Adaptive Immunity to Variants of Concern of SARS-CoV-2 Including OmicronSemantic proximity Read

Durability of SARS-CoV-2-specific T cell responses at 12-months post-infectionSemantic proximity Read

Prolonged evolution of the human B cell response to SARS-CoV-2 infectionSemantic proximity Read

Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infectionSemantic proximity Read