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Article

Rhabdoid tumor: gene expression clues to pathogenesis and potential therapeutic targets.

Laboratory investigation; a journal of technical methods and pathology - 1 May 2010

Gadd Samantha, Sredni Simone Treiger, Huang Chiang-Ching, Perlman Elizabeth J

Abstract excerpt

Rhabdoid tumors (RT) are aggressive tumors characterized by genetic loss of SMARCB1 (SNF5, INI-1), a component of the SWI/SNF chromatin remodeling complex. No effective treatment is currently available. This study seeks to shed light on the SMARCB1-mediated pathogenesis of RT and to discover potential therapeutic targets. Global gene expression of 10 RT was compared with 12 cellular mesoblastic nephromas, 16...

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Topics

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Share to Chromosomal Proteins, Non-Histone
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 20212451
DOI: 10.1038/labinvest.2010.66
PMCID: PMC2868345

Genes

SMARCB1
DOCK4
PTPRK
CCND1
MYC
NQO1
PLOD1
PTN
SOX10
SPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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