Article

Using the structure of genome data in the design of deep neural networks for predicting amyotrophic lateral sclerosis from genotype

2019-01-29

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease caused by aberrations in the genome. While several disease-causing variants have been identified, a major part of heritability remains unexplained. ALS is believed to have a complex genetic basis where nonadditive combinations of variants constitute disease, which cannot be picked up using the linear models employed in classical genotype-phenotype...

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Literature Corpus work: 6643601e-52fc-5a10-bf8d-ea1d0a479f63
DOI: 10.1101/533679

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