Article

Anti-inflammatory effects of WFS1 in pancreatic β-cells

2022-02-09

Abstract excerpt

Wolfram syndrome is a rare genetic disorder characterized by juvenile-onset diabetes mellitus, optic nerve atrophy, hearing loss, diabetes insipidus, and progressive neurodegeneration. Pathogenic variants in the WFS1 gene are the main causes of Wolfram syndrome. WFS1 encodes a transmembrane protein localized to the endoplasmic reticulum (ER) and regulates the unfolded protein response (UPR). Loss of function of...

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Literature Corpus work: 5bf3b050-4aa2-5933-a9e7-e29ddf8fb5c5
DOI: 10.1101/2022.02.09.479773

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