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Article

Neuroplastin-55 is a receptor of Manf and protects against diet-induced obesity by promoting adipose browning.

Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2025

Jia Qingyi, Zhang Jinhang, Song Haiying, Chen Jiahao, Zhang Zhenyu, Yu Huihui, Chen Yi, Liu Qinhui, Jing Xiandan, Xu Haixia, Li Jingwei, Xiong Yimin, Ma Meilin, Yang Na, Li Junyan, Xu Yining, Li Yanping, He Jinhan

Abstract excerpt

The browning of white adipose tissue (WAT) enhances thermogenesis and holds great potential in obesity treatment. Membrane receptors have been proven as essential factors during WAT browning. In this study, we found that transmembrane receptor neuroplastin-55 (Np55) was markedly upregulated in the adipose tissue of both obese individuals and mice. Fat-specific Np55 knockout (Np55FKO) sensitized mice to high-fat...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 41284862
DOI: 10.1073/pnas.2515526122
PMCID: PMC12685124

Genes

TRAF2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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