Article

CFTR mRNAs with nonsense codons are degraded by the SMG6-mediated endonucleolytic pathway

2021-08-24

Abstract excerpt

<title>Abstract</title> <p>Cystic fibrosis is caused by loss of function mutations in the <italic>cystic fibrosis</italic> <italic>transmembrane conductance regulator </italic>(<italic>CFTR</italic>) gene resulting in severe lung disease. Nearly 10% of cystic fibrosis patients have at least one <italic>CFTR </italic>allele with a nonsense mutation that generates a nonsense codon in the mRNA. Nonsense mutations ca...

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Literature Corpus work: 65edf0ad-647b-5236-955b-1af53d013548
DOI: 10.21203/rs.3.rs-800274/v1

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