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Article

Nonsense-mediated mRNA decay affects nonsense transcript levels and governs response of cystic fibrosis patients to gentamicin.

The Journal of clinical investigation - 1 Mar 2007

Linde Liat, Boelz Stephanie, Nissim-Rafinia Malka, Oren Yifat S, Wilschanski Michael, Yaacov Yasmin, Virgilis Dov, Neu-Yilik Gabriele, Kulozik Andreas E, Kerem Eitan, Kerem Batsheva

Abstract excerpt

Aminoglycosides can readthrough premature termination codons (PTCs), permitting translation of full-length proteins. Previously we have found variable efficiency of readthrough in response to the aminoglycoside gentamicin among cystic fibrosis (CF) patients, all carrying the W1282X nonsense mutation. Here we demonstrate that there are patients in whom the level of CF transmembrane conductance regulator (CFTR)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17290305
DOI: 10.1172/JCI28523
PMCID: PMC1783999

Genes

CFTR
ASNS
RPL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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