Article
The NSAID glafenine rescues class 2 CFTR mutants via cyclooxygenase 2 inhibition of the arachidonic acid pathway.
Scientific reports - 17 Mar 2022
Carlile Graeme W, Yang Qi, Matthes Elizabeth, Liao Jie, Birault Véronique, Sneddon Helen F, Poole Darren L, Hall Callum J, Hanrahan John W, Thomas David Y
Abstract excerpt
Most cases of cystic fibrosis (CF) are caused by class 2 mutations in the cystic fibrosis transmembrane regulator (CFTR). These proteins preserve some channel function but are retained in the endoplasmic reticulum (ER). Partial rescue of the most common CFTR class 2 mutant, F508del-CFTR, has been achieved through the development of pharmacological chaperones (Tezacaftor and Elexacaftor) that bind CFTR directly....
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