Article

A post-mitotic bistable switch actively safeguards mature neurons against reciprocal transdifferentiation <i>in vivo</i>

2026-06-22

Abstract excerpt

<h4>ABSTRACT</h4> How mature cells actively defend their identity against alternative fates is poorly understood. Here we show that two types of fully differentiated Drosophila somatosensory neurons, derived from distinct lineages, are continuously prevented from transdifferentiating into one another by a post-mitotic bistable switch. Two homeodomain transcription factors, Hmx and Cut, are co-expressed in both n...

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Literature Corpus work: 65a33dda-892a-5401-8e41-ac46319f6512
DOI: 10.64898/2026.06.19.733455

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