Article

Formation of multinucleated globoid cells in Krabbe iPSC-derived microglia cultures: a preliminary investigation

2021-10-16

Abstract excerpt

Globoid cell leukodystrophy (Krabbe disease) is a severe demyelinating, neurodegenerative lysosomal storage disorder caused by deficiency in glycosphingolipid catabolic enzyme galactosylceramidase (GALC). Histologically, Krabbe disease is characterized by the appearance of large multinucleated globoid cells that express classical macrophage markers (both of brain-resident microglia and peripheral monocyte-derived)...

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Literature Corpus work: 659b5432-94e7-5c4a-9a92-e9524b0bc282
DOI: 10.1101/2021.10.16.464657

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