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Article

Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasm

2023-08-21

Abstract excerpt

In some patients with myeloproliferative neoplasms (MPN), two genetic mutations are often found, JAK2 V617F and one in the TET2 gene. Whether or not one mutation is present will influence how the other subsequent mutation affects the regulation of gene expression. When both mutations are present, the order of their occurrence has been shown to influence disease progression and prognosis. We propose a nonlinear ord...

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Identifiers and source

Literature Corpus work
65836bb3-5260-5073-8e97-b7b8d9dff89d
DOI
10.1101/2023.08.16.23294177
Open publication

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Order-of-mutation effects on cancer progression: models for myeloproliferative neoplasmDOI 10.1101/2023.08.16.23294177
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