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Article

Expression, Purification, Characterization and Cellular Uptake of MeCP2 Variants.

The protein journal - 1 Apr 2022

Beribisky Alexander V, Steinkellner Hannes, Geislberger Sofia, Huber Anna, Sarne Victoria, Christodoulou John, Laccone Franco

Abstract excerpt

The transcriptional regulator Methyl-CpG-binding protein 2 (MeCP2) is an intrinsically disordered protein, mutations in which, are implicated in the onset of Rett Syndrome, a severe and debilitating neurodevelopmental disorder. Delivery of this protein fused to the cell-penetrating peptide TAT could allow for the intracellular replenishment of functional MeCP2 and hence potentially serve as a prospective Rett...

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Identifiers

PMID: 35546650
DOI: 10.1007/s10930-022-10054-9
PMCID: PMC9122891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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