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Article

Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for pandemrix-associated narcolepsy risk.

PloS one - 1 Jan 2014

Vaarala Outi, Vuorela Arja, Partinen Markku, Baumann Marc, Freitag Tobias L, Meri Seppo, Saavalainen Päivi, Jauhiainen Matti, Soliymani Rabah, Kirjavainen Turkka, Olsen Päivi, Saarenpää-Heikkilä Outi, Rouvinen Juha, Roivainen Merja, Nohynek Hanna, Jokinen Jukka, Julkunen Ilkka, Kilpi Terhi

Abstract excerpt

BACKGROUND: Narcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms are poorly understood. Vaccine-attributable risk of narcolepsy reported so far with the AS03 adjuvanted H1N1 vaccination Pandemrix has been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25501681
DOI: 10.1371/journal.pone.0114361
PMCID: PMC4266499

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25501681-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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