Article
Antigenic differences between AS03 adjuvanted influenza A (H1N1) pandemic vaccines: implications for pandemrix-associated narcolepsy risk.
PloS one - 1 Jan 2014
Vaarala Outi, Vuorela Arja, Partinen Markku, Baumann Marc, Freitag Tobias L, Meri Seppo, Saavalainen Päivi, Jauhiainen Matti, Soliymani Rabah, Kirjavainen Turkka, Olsen Päivi, Saarenpää-Heikkilä Outi, Rouvinen Juha, Roivainen Merja, Nohynek Hanna, Jokinen Jukka, Julkunen Ilkka, Kilpi Terhi
Abstract excerpt
BACKGROUND: Narcolepsy results from immune-mediated destruction of hypocretin secreting neurons in hypothalamus, however the triggers and disease mechanisms are poorly understood. Vaccine-attributable risk of narcolepsy reported so far with the AS03 adjuvanted H1N1 vaccination Pandemrix has been manifold compared to the AS03 adjuvanted Arepanrix, which contained differently produced H1N1 viral antigen...
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