Article
Oxysterol accumulation in aging cells alters GPCR signalling
2024-05-14
Abstract excerpt
Organismal aging is accompanied by the accumulation of senescent cells in the body, which drives tissue dysfunction. Senescent cells have a distinctive profile, including proliferation arrest, resistance to apoptosis, altered gene expression, and high inflammation. Despite global signalling and metabolic dysregulation during senescence, the underlying reasons for changes in signalling remain unclear. GPCRs are piv...
Topics
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- Antioxidant Activity and Oxidative Stress
- Cholesterol and Lipid Metabolism
- Drug Transport and Resistance Mechanisms
- Hedgehog Signaling Pathway Studies
- Neuroscience and Neuropharmacology Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Receptor Mechanisms and Signaling
- Sphingolipid Metabolism and Signaling
Identifiers and source
- Literature Corpus work
- 65647462-f459-502d-bfb8-ba415912b105
- DOI
- 10.1101/2024.05.09.593443