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Human aging and disease: Lessons from age-related macular degeneration

26 Feb 2018

Abstract excerpt

Aging is the most significant risk factor associated with chronic disease in humans. The accumulation of genetic damage throughout life leads to a variety of biological aberrations, including disrupted protein homeostasis, metabolic dysfunction, and altered cellular signaling. Such changes ultimately result in cellular senescence, death, or transformation to uncontrolled proliferation, thereby compromising human...

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PMID: 29483257
DOI: 10.1073/pnas.1721033115

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