Article

Tumor CTR1 and serum copper dynamics reveal a coordinated copper axis linked to high-grade triple-negative breast cancer biology

2025-12-27

Abstract excerpt

<h4>Background</h4> Copper is an essential nutrient required for energy production, antioxidant defense, and connective tissue maturation, yet has emerged as a metabolic vulnerability in cancer. CTR1 ( SLC31A1 ), the high-affinity copper importer, mediates cellular copper uptake, and its upregulation may signal increased copper demand in tumor cells. The dynamics of copper regulation across tumor growth, aggress...

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Literature Corpus work: 655dfd3a-8e3b-576c-b0ed-62dafcd45442
DOI: 10.64898/2025.12.18.25342516

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