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A Cell of Origin Gene Signature Indicates Human Bladder Cancer Has Distinct Cellular Progenitors

19 Dec 2013

Abstract excerpt

There are two distinct forms of urothelial (bladder) cancer: muscle-invasive (MI) and nonmuscle invasive (NMI) disease. Since it is currently believed that bladder cancer arises by transformation of urothelial cells of the basal layer, bladder cancer stem cells (CSCs) have been isolated based on expression markers found in such cells. However, these CSCs have only been identified in MI tumors raising the...

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PMID: 24357085
DOI: 10.1002/stem.1625

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