Article

Within-host rhinovirus evolution in upper and lower respiratory tract highlights capsid variability and mutation-independent compartmentalization

2023-05-11

Abstract excerpt

<h4>Background</h4> Human rhinovirus (HRV) infections can progress from the upper (URT) to lower (LRT) respiratory tract in immunocompromised individuals, causing high rates of fatal pneumonia. Little is known about how HRV evolves within hosts during infection. <h4>Methods</h4> We sequenced HRV complete genomes from 12 hematopoietic cell transplant patients with prolonged infection for up to 190 days from both...

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Literature Corpus work: 650f220a-c199-5c8b-b76a-975766ef38b8
DOI: 10.1101/2023.05.11.540440

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