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Article

Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution.

Science (New York, N.Y.) - 3 Apr 2009

Palmenberg Ann C, Spiro David, Kuzmickas Ryan, Wang Shiliang, Djikeng Appolinaire, Rathe Jennifer A, Fraser-Liggett Claire M, Liggett Stephen B

Abstract excerpt

Infection by human rhinovirus (HRV) is a major cause of upper and lower respiratory tract disease worldwide and displays considerable phenotypic variation. We examined diversity by completing the genome sequences for all known serotypes (n = 99). Superimposition of capsid crystal structure and optimal-energy RNA configurations established alignments and phylogeny. These revealed conserved motifs; clade-specific...

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Identifiers

PMID: 19213880
DOI: 10.1126/science.1165557
PMCID: PMC3923423

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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