Article

Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammation

2021-11-27

Abstract excerpt

Mesenchymal stem cell (MSC) transplantation alleviates metabolic defects in diseased recipient cells by intercellular mitochondrial transport (IMT). However, the effect of host metabolic conditions on MSCs in general, and IMT in particular, has largely remained unexplored. This study has identified a molecular pathway that primarily governs the metabolic function and IMT of MSCs. We found underlying mitochondrial...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 65046236-48ec-59bd-b62b-a631594cf93f
DOI: 10.1101/2021.11.27.470183

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Obesity impairs therapeutic efficacy of mesenchymal stem cells by inhibiting cardiolipin-dependent mitophagy and intercellular mitochondrial transfer in mouse models of allergic airway inflammationDOI 10.1101/2021.11.27.470183Read

Mitochondrial Dysfunction and Metabolic Reprogramming in Obesity and AsthmaSemantic proximity Read

Mesenchymal Stem Cells Shift Mitochondrial Dynamics and Enhance Oxidative Phosphorylation in Recipient CellsSemantic proximity Read

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.Semantic proximity Read

Mitochondrial Dysfunction and Diabetes: Is Mitochondrial Transfer a Friend or Foe?Semantic proximity Read

Autophagy inhibition in early but not in later stages prevents 3T3-L1 differentiation: Effect on mitochondrial remodelingSemantic proximity Read

Phenotypic Discovery of SB1501, an Anti-obesity Agent, through Modulating Mitochondrial Activity.Semantic proximity Read

STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS InductionSemantic proximity Read

Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiationSemantic proximity Read

Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell modelsSemantic proximity Read

Tafazzin deficiency in mouse mesenchymal stem cells potentiates their immunosuppression and impairs activated B lymphocyte immune functionSemantic proximity Read

A direct tissue-grafting approach to increasing endogenous brown fat.Semantic proximity Read

TSLP regulates mitochondrial ROS-induced mitophagy via histone modification in human monocytesSemantic proximity Read