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Article

Mesenchymal Stromal Cells Deficient in Autophagy Proteins Are Susceptible to Oxidative Injury and Mitochondrial Dysfunction.

American journal of respiratory cell and molecular biology - 1 Mar 2017

Ghanta Sailaja, Tsoyi Konstantin, Liu Xiaoli, Nakahira Kiichi, Ith Bonna, Coronata Anna A, Fredenburgh Laura E, Englert Joshua A, Piantadosi Claude A, Choi Augustine M K, Perrella Mark A

Abstract excerpt

Oxidative stress resulting from inflammatory responses that occur during acute lung injury and sepsis can initiate changes in mitochondrial function. Autophagy regulates cellular processes in the setting of acute lung injury, sepsis, and oxidative stress by modulating the immune response and facilitating turnover of damaged cellular components. We have shown that mesenchymal stromal cells (MSCs) improve survival...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27636016
DOI: 10.1165/rcmb.2016-0061OC
PMCID: PMC5359535

Genes

BECN1
MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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