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Article

Codon modification of Tuba1a alters mRNA levels and causes a severe neurodevelopmental phenotype in mice.

Scientific reports - 21 Jan 2023

Leca Ines, Phillips Alexander William, Ushakova Lyubov, Cushion Thomas David, Keays David Anthony

Abstract excerpt

The tubulinopathies are an umbrella of rare diseases that result from mutations in tubulin genes and are frequently characterised by severe brain malformations. The characteristics of a given disease reflect the expression pattern of the transcript, the function of a given tubulin gene, and the role microtubules play in a particular cell type. Mouse models have proved to be valuable tools that have provided...

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PMID: 36681692
DOI: 10.1038/s41598-023-27782-2
PMCID: PMC9867703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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