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Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps

18 Mar 2020

Abstract excerpt

Mitophagy, a conserved intracellular process by which mitochondria are eliminated via the autophagic machinery, is a quality control mechanism which facilitates maintenance of a functional mitochondrial network and cell homeostasis, making it a key process in development and longevity. Mitophagy has been linked to multiple human disorders, especially neurodegenerative diseases where the long-lived neurons are...

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PMID: 32258042
DOI: 10.3389/fcell.2020.00171

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