Article

A New Approach to Modeling LGMDR1: Pyrvinium-Treated <i>capn3b</i> crispant Zebrafish

2025-11-27

Abstract excerpt

The lack of an accurate animal model for LGMDR1 is a major obstacle to therapeutic development. While murine models do not replicate the human gene expression profile, zebrafish offers a promising alternative. We generated a capn3b mutant zebrafish, which showed minimal phenotypic changes. However, when this model was treated with pyrvinium, a Wnt signaling inhibitor, its gene expression patterns mimic those obse...

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Literature Corpus work: 640711ec-306a-590b-9614-f0c0eb676a54
DOI: 10.1101/2025.11.25.690358

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