Article

Conditioned medium from painful schwannomatosis tumors increases pain behaviors in mice

2024-04-10

Abstract excerpt

The majority of schwannomatosis (SWN) patients experience debilitating pain. Yet, it is not known why only some schwannomas cause pain or whether mutations in SWN-related genes, (SMARCB1 or LZTR1) differentially influence pain signaling pathways. Here, we established cell lines from SWN tumors resected from patients with varying degrees of pain and bearing mutations in different SWN-related mutations. Compared wit...

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Literature Corpus work: 64042753-d07d-5999-a3e1-bf5e25ca4c9e
DOI: 10.1101/2024.04.06.588413

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