Article

Parthenolide enhances imatinib activity in gastrointestinal stromal tumor models through stress-associated apoptosis

2026-07-13

Abstract excerpt

<title>Abstract</title> <p>Purpose Imatinib remains a key treatment for gastrointestinal stromal tumors (GISTs), but incomplete response and acquired resistance limit durable disease control. This study evaluated whether parthenolide (PTL) enhances imatinib activity in GIST models and explored associated stress-response mechanisms. Methods Public GIST transcriptomic datasets were analyzed to identify cell-fate...

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Literature Corpus work: 63f8f7bb-8aba-54e2-9b4e-a1b06c8c1ad4
DOI: 10.21203/rs.3.rs-10231293/v1

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