Article
[Somatic mutation of the V617F JAK2 gene in patients of the cardiovascular diseases].
Terapevticheskii arkhiv - 15 Jul 2019
Olkhovskiy I A, Gorbenko A S, Stolyar M A, Grischenko D A, Tkachenko O A, Martsinkevich T L
Abstract excerpt
The JAK2 V617F somatic mutation is one of the most frequent markers of CHIP (clonal hematopoiesis of indeterminate potential). CHIP is characterized by the presence of a myeloid cells clone in peripheral blood in the absence of the sufficient reasons to diagnose the hematologic disease. The CHIP is proposed as a potential independent risk factor for vascular pathology. The aim of this study is to identify...
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